Prognostic correlation of increased angiogenesis in acute myeloid leukemia with cytogenetics.

the identification of mouse basophils as interleukin-4 (IL-4)– producing, high-affinity FceR-positive, histamine-containing cells sorted from mouse bone marrow and spleen,3 previously referred to as non-B, non-T cells.10 The ultrastructural characteristics of these basophils are described and contrasted with those of FceR-positive mast cells and with FceR-negative neutrophils and eosinophils in detail.4 Further ultrastructural studies with this model revealed that mouse basophils are FceR-positive and c-kit–negative, whereas mast cells are FceR-positive and c-kit–positive, and that mouse basophils did not thrive in cultures supplemented with interleukin-3 (IL-3) or stem cell factor (SCF), on the one hand, or with a combination of these 2 mouse mast cell growth factors, on the other.5 In all of these references,2-5 ultrastructural images of mouse basophils identical to the basophil in Verbeek et al’s figure 1A-B are included.